2023

Deiana, Marco; Andrés Castán, José María; Josse, Pierre; Kahsay, Abraha; Sánchez, Darío Puchán; Morice, Korentin; Gillet, Natacha; Ravindranath, Ranjitha; Patel, Ankit Kumar; Sengupta, Pallabi; Obi, Ikenna; Rodriguez-Marquez, Eva; Khrouz, Lhoussain; Dumont, Elise; Abad Galán, Laura; Allain, Magali; Walker, Bright; Ahn, Hyun Seo; Maury, Olivier; Blanchard, Philippe; Le Bahers, Tangui; Öhlund, Daniel; von Hofsten, Jonas; Monnereau, Cyrille; Cabanetos, Clément; Sabouri, Nasim

A new G-quadruplex-specific photosensitizer inducing genome instability in cancer cells by triggering oxidative DNA damage and impeding replication fork progression Journal Article

In: vol. 51, no. 12, pp. 6264–6285, 2023, ISSN: 1362-4962.

Abstract | Links | BibTeX | Altmetric | Tags: Genetics

Deiana, Marco; Chand, Karam; Chorell, Erik; Sabouri, Nasim

Parallel G-Quadruplex DNA Structures from Nuclear and Mitochondrial Genomes Trigger Emission Enhancement in a Nonfluorescent Nano-aggregated Fluorine–Boron-Based Dye Journal Article

In: J. Phys. Chem. Lett., vol. 14, no. 7, pp. 1862–1869, 2023, ISSN: 1948-7185.

Links | BibTeX | Altmetric | Tags: General Materials Science, Physical and Theoretical Chemistry

2022

Deiana, Marco; Josse, Pierre; Dalinot, Clément; Osmolovskyi, Artem; Marqués, Pablo Simón; Castán, José María Andrés; Galán, Laura Abad; Allain, Magali; Khrouz, Lhoussain; Maury, Olivier; Bahers, Tangui Le; Blanchard, Philippe; Dabos-Seignon, Sylvie; Monnereau, Cyrille; Sabouri, Nasim; Cabanetos, Clément

Site-selected thionated benzothioxanthene chromophores as heavy-atom-free small-molecule photosensitizers for photodynamic therapy Journal Article

In: Commun Chem, vol. 5, no. 1, 2022, ISSN: 2399-3669.

Abstract | Links | BibTeX | Altmetric | Tags: Biochemistry, Environmental Chemistry, General Chemistry, Materials Chemistry

Jamroskovic, Jan; Deiana, Marco; Sabouri, Nasim

Probing the folding pathways of four-stranded intercalated cytosine-rich motifs at single base-pair resolution Journal Article

In: Biochimie, vol. 199, pp. 81–91, 2022, ISSN: 1638-6183.

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2021

Deiana, Marco; Mosser, Maëlle; Bahers, Tangui Le; Dumont, Elise; Dudek, Marta; Denis-Quanquin, Sandrine; Sabouri, Nasim; Andraud, Chantal; Matczyszyn, Katarzyna; Monnereau, Cyrille; Guy, Laure

Light-induced in situ chemical activation of a fluorescent probe for monitoring intracellular G-quadruplex structures Journal Article

In: Nanoscale, vol. 13, no. 32, pp. 13795–13808, 2021, ISSN: 2040-3372.

Abstract | Links | BibTeX | Altmetric | Tags:

Deiana, Marco; Obi, Ikenna; Andreasson, Måns; Tamilselvi, Shanmugam; Chand, Karam; Chorell, Erik; Sabouri, Nasim

A Minimalistic Coumarin Turn-On Probe for Selective Recognition of Parallel G-Quadruplex DNA Structures Journal Article

In: ACS Chem Biol, vol. 16, no. 8, pp. 1365–1376, 2021, ISSN: 1554-8937.

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Yan, Kevin Kok-Phen; Obi, Ikenna; Sabouri, Nasim

The RGG domain in the C-terminus of the DEAD box helicases Dbp2 and Ded1 is necessary for G-quadruplex destabilization Journal Article

In: Nucleic Acids Res, vol. 49, no. 14, pp. 8339–8354, 2021, ISSN: 1362-4962.

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2020

Deiana, Marco; Jamroskovic, Jan; Obi, Ikenna; Sabouri, Nasim

Unravelling the cellular emission fingerprint of the benchmark G-quadruplex-interactive compound Phen-DC Journal Article

In: Chem Commun (Camb), vol. 56, no. 91, pp. 14251–14254, 2020, ISSN: 1364-548X.

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Prasad, Bagineni; Das, Rabindra Nath; Jamroskovic, Jan; Kumar, Rajendra; Hedenström, Mattias; Sabouri, Nasim; Chorell, Erik

The Relation Between Position and Chemical Composition of Bis-Indole Substituents Determines Their Interactions with G-Quadruplex DNA Journal Article

In: Chemistry, vol. 26, no. 43, pp. 9561–9572, 2020, ISSN: 1521-3765.

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Deiana, Marco; Chand, Karam; Jamroskovic, Jan; Das, Rabindra Nath; Obi, Ikenna; Chorell, Erik; Sabouri, Nasim

A site-specific self-assembled light-up rotor probe for selective recognition and stabilization of c-MYC G-quadruplex DNA Journal Article

In: Nanoscale, vol. 12, no. 24, pp. 12950–12957, 2020, ISSN: 2040-3372.

Abstract | Links | BibTeX | Altmetric | Tags:

Deiana, Marco; Chand, Karam; Jamroskovic, Jan; Obi, Ikenna; Chorell, Erik; Sabouri, Nasim

A Light-up Logic Platform for Selective Recognition of Parallel G-Quadruplex Structures via Disaggregation-Induced Emission Journal Article

In: Angew Chem Int Ed Engl, vol. 59, no. 2, pp. 896–902, 2020, ISSN: 1521-3773.

Abstract | Links | BibTeX | Altmetric | Tags:

Jamroskovic, Jan; Doimo, Mara; Chand, Karam; Obi, Ikenna; Kumar, Rajendra; Brännström, Kristoffer; Hedenström, Mattias; Das, Rabindra Nath; Akhunzianov, Almaz; Deiana, Marco; Kasho, Kazutoshi; Sato, Sebastian Sulis; Pourbozorgi, Parham L; Mason, James E; Medini, Paolo; Öhlund, Daniel; Wanrooij, Sjoerd; Chorell, Erik; Sabouri, Nasim

Quinazoline Ligands Induce Cancer Cell Death through Selective STAT3 Inhibition and G-Quadruplex Stabilization Journal Article

In: J Am Chem Soc, vol. 142, no. 6, pp. 2876–2888, 2020, ISSN: 1520-5126.

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Obi, Ikenna; Rentoft, Matilda; Singh, Vandana; Jamroskovic, Jan; Chand, Karam; Chorell, Erik; Westerlund, Fredrik; Sabouri, Nasim

Stabilization of G-quadruplex DNA structures in Schizosaccharomyces pombe causes single-strand DNA lesions and impedes DNA replication Journal Article

In: Nucleic Acids Res, vol. 48, no. 19, pp. 10998–11015, 2020, ISSN: 1362-4962.

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2019

Jamroskovic, Jan; Obi, Ikenna; Movahedi, Anahita; Chand, Karam; Chorell, Erik; Sabouri, Nasim

Identification of putative G-quadruplex DNA structures in S. pombe genome by quantitative PCR stop assay Journal Article

In: DNA Repair (Amst), vol. 82, pp. 102678, 2019, ISSN: 1568-7856.

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2018

Prasad, Bagineni; Jamroskovic, Jan; Bhowmik, Sudipta; Kumar, Rajendra; Romell, Tajanena; Sabouri, Nasim; Chorell, Erik

Flexible Versus Rigid G-Quadruplex DNA Ligands: Synthesis of Two Series of Bis-indole Derivatives and Comparison of Their Interactions with G-Quadruplex DNA Journal Article

In: Chemistry, vol. 24, no. 31, pp. 7926–7938, 2018, ISSN: 1521-3765.

Abstract | Links | BibTeX | Altmetric | Tags:

Mohammad, Jani B; Wallgren, Marcus; Sabouri, Nasim

The Pif1 signature motif of Pfh1 is necessary for both protein displacement and helicase unwinding activities, but is dispensable for strand-annealing activity Journal Article

In: Nucleic Acids Res, vol. 46, no. 16, pp. 8516–8531, 2018, ISSN: 1362-4962.

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2017

Sabouri, Nasim

The functions of the multi-tasking Pfh1 helicase Journal Article

In: Curr Genet, vol. 63, no. 4, pp. 621–626, 2017, ISSN: 1432-0983.

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2016

Jamroskovic, Jan; Livendahl, Madeleine; Eriksson, Jonas; Chorell, Erik; Sabouri, Nasim

Identification of Compounds that Selectively Stabilize Specific G-Quadruplex Structures by Using a Thioflavin T-Displacement Assay as a Tool Journal Article

In: Chemistry, vol. 22, no. 52, pp. 18932–18943, 2016, ISSN: 1521-3765.

Abstract | Links | BibTeX | Altmetric | Tags:

Livendahl, Madeleine; Jamroskovic, Jan; Ivanova, Svetlana; Demirel, Peter; Sabouri, Nasim; Chorell, Erik

Design and Synthesis of 2,2′-Diindolylmethanes to Selectively Target Certain G-Quadruplex DNA Structures Journal Article

In: Chemistry, vol. 22, no. 37, pp. 13004–13009, 2016, ISSN: 1521-3765.

Abstract | Links | BibTeX | Altmetric | Tags:

McDonald, Karin R; Guise, Amanda J; Pourbozorgi-Langroudi, Parham; Cristea, Ileana M; Zakian, Virginia A; Capra, John A; Sabouri, Nasim

Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity Journal Article

In: PLoS Genet, vol. 12, no. 9, pp. e1006238, 2016, ISSN: 1553-7404.

Abstract | Links | BibTeX | Altmetric | Tags:

Wallgren, Marcus; Mohammad, Jani B; Yan, Kok-Phen; Pourbozorgi-Langroudi, Parham; Ebrahimi, Mahsa; Sabouri, Nasim

G-rich telomeric and ribosomal DNA sequences from the fission yeast genome form stable G-quadruplex DNA structures in vitro and are unwound by the Pfh1 DNA helicase Journal Article

In: Nucleic Acids Res, vol. 44, no. 13, pp. 6213–6231, 2016, ISSN: 1362-4962.

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2014

McDonald, Karin R; Sabouri, Nasim; Webb, Christopher J; Zakian, Virginia A

The Pif1 family helicase Pfh1 facilitates telomere replication and has an RPA-dependent role during telomere lengthening Journal Article

In: DNA Repair (Amst), vol. 24, pp. 80–86, 2014, ISSN: 1568-7856.

Abstract | Links | BibTeX | Altmetric | Tags:

Fusté, Javier Miralles; Shi, Yonghong; Wanrooij, Sjoerd; Zhu, Xuefeng; Jemt, Elisabeth; Persson, Örjan; Sabouri, Nasim; Gustafsson, Claes M; Falkenberg, Maria

In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replication Journal Article

In: PLoS Genet, vol. 10, no. 12, pp. e1004832, 2014, ISSN: 1553-7404.

Abstract | Links | BibTeX | Altmetric | Tags:

Sabouri, Nasim; Capra, John A; Zakian, Virginia A

The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage Journal Article

In: BMC Biol, vol. 12, pp. 101, 2014, ISSN: 1741-7007.

Abstract | Links | BibTeX | Altmetric | Tags:

2012

Sabouri, Nasim; McDonald, Karin R; Webb, Christopher J; Cristea, Ileana M; Zakian, Virginia A

DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase Journal Article

In: Genes Dev, vol. 26, no. 6, pp. 581–593, 2012, ISSN: 1549-5477.

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2010

Bochman, Matthew L; Sabouri, Nasim; Zakian, Virginia A

Unwinding the functions of the Pif1 family helicases Journal Article

In: DNA Repair (Amst), vol. 9, no. 3, pp. 237–249, 2010, ISSN: 1568-7856.

Abstract | Links | BibTeX | Altmetric | Tags:

2009

Sabouri, Nasim; Johansson, Erik

Translesion synthesis of abasic sites by yeast DNA polymerase epsilon Journal Article

In: J Biol Chem, vol. 284, no. 46, pp. 31555–31563, 2009, ISSN: 1083-351X.

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2008

Sabouri, Nasim; Viberg, Jörgen; Goyal, Dinesh Kumar; Johansson, Erik; Chabes, Andrei

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage Journal Article

In: Nucleic Acids Res, vol. 36, no. 17, pp. 5660–5667, 2008, ISSN: 1362-4962.

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2006

Asturias, Francisco J; Cheung, Iris K; Sabouri, Nasim; Chilkova, Olga; Wepplo, Daniel; Johansson, Erik

Structure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo-electron microscopy Journal Article

In: Nat Struct Mol Biol, vol. 13, no. 1, pp. 35–43, 2006, ISSN: 1545-9993.

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2004

Garg, Parie; Stith, Carrie M; Sabouri, Nasim; Johansson, Erik; Burgers, Peter M

Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication Journal Article

In: Genes Dev, vol. 18, no. 22, pp. 2764–2773, 2004, ISSN: 0890-9369.

Abstract | Links | BibTeX | Altmetric | Tags: