Guanine-rich sequences and the complementary Cytosine-rich sequences of the genome have the propensity to form non-canonical structures known as G-quadruplexes (G4s) and intercalated motifs (iMs), respectively. The abundance of these sequences in specific areas of the genome, such as telomeres and promoter regions of oncogenes, have made them the focal point of many research studies. Despite that G4 structures have been widely discussed and recognized as a promising targets in cancer therapy, very little is known about its complementary structure, the iMs.

Our aim is to investigate the interplay and effects of G4s and iMs on DNA metabolism, as well as the potential roles that proteins (e.g. helicases) and small organic molecules exert towards the regulation of folding/unfolding of these secondary structures in human and yeast model systems. Our attention is also directed to the study of photoactivated compounds that target G4s or iMs for therapeutic and diagnostic anticancer applications.